RAF Typhoon FGR4s have conducted a mission with France's air force in a combined operation on an underground arms cache in Syrian territory used by the IS group, according to the British defence ministry.
The site, located using reconnaissance, was thought to be containing munitions and bombs, the statement said, and was positioned in mountains just north of the ancient city of Palmyra in central Syria.
"Our fighter planes employed precision-guided Paveway IV munitions to target a series of approach shafts leading to the facility... preliminary assessments are that the target was engaged successfully," officials stated.
There was no sign of any civilian casualties in the strike on Saturday evening and each participating jet made a safe return, the defence officials confirmed.
The Typhoon FGR4s were supported by a Voyager refuelling tanker.
Daesh - referred to as the so-called Islamic State - enforced extremist governance over large swathes of Iraq and Syria until 2019.
"This strike shows the UK's leading role, and determination to operate in unison with our partners, to eradicate any re-emergence of IS and their violent and radical beliefs in the Middle East," the British Defence Secretary the minister stated.
UK warplanes have performed surveillance missions over Syrian airspace to "forestall any attempted comeback" of IS following its routing at the battle of Baghuz in 2019, the authorities noted.
"I extend gratitude to every member of the UK armed forces participating in this mission for their professionalism and their bravery," the Defence Secretary commented. "Including them were a great many UK service members on duty over Christmas and New Year. This action, to take out militants who endanger our safety, highlights how UK forces are prepared to act, all year round, ensuring Britain's security within its borders and strong abroad."
Last December, the US military executed what it termed a "large-scale strike" against Islamic State objectives in Syria, after an assault claimed the lives of two US servicemembers and a civilian interpreter in Palmyra.
The United Nations reports Islamic State still maintains between 5,000 and 7,000 militants in both countries.
